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Malabar nut can help fight symptoms, says study, Health News, ET HealthWorld

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Hyderabad: Malabar nut can help fight symptoms, says studyHyderabad: Malabar nut (Adhatoda vasica), a common herb popularised a few years ago by the Hyderabad Metropolitan Water Supply and Sewerage Board (HMWS&SB), is now the centre of attraction for researchers, who are searching for a drug to cure the pandemic virus.

Researchers drawn from several national institutions including city-based Centre for Cellular and Molecular Biology (CCMB, have found that certain active pharmaceutical compounds present in Malabar nut (Addasaram in Telugu, Adusa in Hindi and Urdu), used mostly in Ayurveda and Unani, could turn out to be the magic medicine for the treatment of novel coronavirus. The labs have now completed the animal studies and plan to take research further.

“Treatment of Adhatoda vasica extract alters the cellular hypoxic (low oxygen) response and modulates the inflammation thrombosis (blood clotting) axis. It reduces lung injury, thrombosis and fibrosis (damage to lung tissue). Moreover, in-silico (computer simulation) and in vitro (in laboratory) analysis suggest it may be able to prevent Covid-19 infection and progression,” researchers said in their study published in the latest issue of the scientific journal, Respiratory Research.

The researchers said the results provide a scientific rationale for Adhatoda vasica in ameliorating hypoxia hyperinflammation features. The study also revealed that the herb has properties that reduce the viral load of Covid-19 and assist genes that help in boosting immunity levels. Apart from CCMB, researchers were drawn from Respiratory Research Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, Delhi, and Centre for Translational Research in Lung Disease, Delhi.

“Covid-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae (post recovery symptoms) including persisting hypoxia and fibrosis. Our recent observations on anti-hypoxic and anti-inflammatory effects of Adhatoda vasica prompted us to explore its effects on relevant preclinical mouse models,” researchers said adding that the properties of this wonder drug could be repurposed for treatment of Covid-19.


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